Simulated data from AntiBiotics for Children with severe Diarrhea (ABCD) trial

Simulated dataset based closely on real data from ABCD trial with 40 covariates and n = 6692 observations. The outcome variable is length-for-age z-score at day 90 of the trial (laz90) and the treatment variable is azithromycin (an_grp_01). Details on the distribution of each variable can be found in *cite paper?*

Usage

data(abcd_data)

Format

An object of class "data.frame"

pid

Participant identification number

an_grp_01

Binary indicator for azithromycin (antibiotic) treatment, 1=assigned azithromycin, 0=assigned placebo

rotavirus_new

Relative quantity of rotavirus in stool sample based on log-10 transformed qPCR cycle threshold values

rotavirus_bin

Binary indicator for rotavirus presence in stool sample (1=rotavirus detected, 0=rotavirus not detected)

norovirus_new

Relative quantity of norovirus in stool sample based on log-10 transformed qPCR cycle threshold values

norovirus_bin

Binary indicator for norovirus presence in stool sample (1=norovirus detected, 0=norovirus not detected)

adenovirus_new

Relative quantity of adenovirus in stool sample based on log-10 transformed qPCR cycle threshold values

adenovirus_bin

Binary indicator for adenovirus presence in stool sample (1=adenovirus detected, 0=adenovirus not detected)

astrovirus_new

Relative quantity of astrovirus in stool sample based on log-10 transformed qPCR cycle threshold values

astrovirus_bin

Binary indicator for astrovirus presence in stool sample (1=astrovirus detected, 0=astrovirus not detected)

sapovirus_new

Relative quantity of sapovirus in stool sample based on log-10 transformed qPCR cycle threshold values

sapovirus_bin

Binary indicator for sapovirus presence in stool sample (1=sapovirus detected, 0=sapovirus not detected)

st_etec_new

Relative quantity of st_etec in stool sample based on log-10 transformed qPCR cycle threshold values

st_etec_bin

Binary indicator for st_etec presence in stool sample (1=st_etec detected, 0=st_etec not detected)

shigella_new

Relative quantity of shigella in stool sample based on log-10 transformed qPCR cycle threshold values

shigella_bin

Binary indicator for shigella presence in stool sample (1=shigella detected, 0=shigella not detected)

campylobacter_new

Relative quantity of campylobacter in stool sample based on log-10 transformed qPCR cycle threshold values

campylobacter_bin

Binary indicator for campylobacter presence in stool sample (1=campylobacter detected, 0=campylobacter not detected)

tepec_new

Relative quantity of tepec in stool sample based on log-10 transformed qPCR cycle threshold values

tepec_bin

Binary indicator for tepec presence in stool sample (1=tepec detected, 0=tepec not detected)

v_cholerae_new

Relative quantity of v_cholerae in stool sample based on log-10 transformed qPCR cycle threshold values

v_cholerae_bin

Binary indicator for v_cholerae presence in stool sample (1=v_cholerae detected, 0=v_cholerae not detected)

salmonella_new

Relative quantity of salmonella in stool sample based on log-10 transformed qPCR cycle threshold values

salmonella_bin

Binary indicator for salmonella presence in stool sample (1=salmonella detected, 0=salmonella not detected)

cryptosporidium_new

Relative quantity of cryptosporidium in stool sample based on log-10 transformed qPCR cycle threshold values

cryptosporidium_bin

Binary indicator for cryptosporidium presence in stool sample (1=cryptosporidium detected, 0=cryptosporidium not detected)

dy1_scrn_vomitall

Factor with two levels for vomiting at screening ("No" = not vomit, "Yes" = vomit)

dy1_scrn_lstools

Number of loose stools in 24 hours prior to enrollment (continuous)

dy1_scrn_sstools

Number of solid stools in 24 hours prior to enrollment (continuous)

dy1_scrn_diardays

Duration (days) of diarrhea illness prior to enrollment (continuous)

dy1_scrn_dehydr

Dehydration status at screening (ordinal, 1 = "No dehydration", 2 = "Some dehydration", 3 = "Severe dehydration")

avemuac

Middle upper arm circumference (continuous)

wfazscore

Weight for age z-score (continuous)

lfazscore

Length for age z-score (continuous)

wflzscore

Weight for length z-score (continuous)

site

Study site (nominal, 2 = Bangladesh, 3 = Kenya, 4 = Malawi, 5 = Mali, 6 = India, 7 = Tanzania, 8 = Pakistan)

dy1_ant_sex

Sex (1 = Male, 2 = Female)

agemchild

Age (in months) (continuous)

an_ses_quintile

SES quintile (ordinal, 1 = 1st quintile, 2 = 2nd quintile, 3 = 3rd quintile, 4 = 4th quintile, 5 = 5th quintile)

an_tothhlt5

Number of children under age 5 years in household (continuous)

rotaseason

Binary indicator for enrollment during rotavirus season (1 = enrolled during rotavirus season, 0 = not enrolled during rotavirus season)

month_en

Month enrolled (1-12 correspond to January-December)

lazd90

Length for age z-score at day 90 post-enrollment

References

coming soon

Examples

data(abcd_data)
head(abcd_data)
#> # A tibble: 6 × 43
#>     pid an_grp_01 rotavirus_new norovirus_new adenovirus_new astrovirus_new
#>   <dbl>     <dbl>         <dbl>         <dbl>          <dbl>          <dbl>
#> 1     1         0             0          0              0                 0
#> 2     2         0             0          0              0                 0
#> 3     3         0             0          0              0                 0
#> 4     4         0             0          4.30           1.41              0
#> 5     5         1             0          0              0                 0
#> 6     6         1             0          0              4.61              0
#> # ℹ 37 more variables: sapovirus_new <dbl>, st_etec_new <dbl>,
#> #   shigella_new <dbl>, campylobacter_new <dbl>, tepec_new <dbl>,
#> #   v_cholerae_new <dbl>, salmonella_new <dbl>, cryptosporidium_new <dbl>,
#> #   rotavirus_bin <dbl>, norovirus_bin <dbl>, adenovirus_bin <dbl>,
#> #   astrovirus_bin <dbl>, sapovirus_bin <dbl>, st_etec_bin <dbl>,
#> #   shigella_bin <dbl>, campylobacter_bin <dbl>, tepec_bin <dbl>,
#> #   v_cholerae_bin <dbl>, salmonella_bin <dbl>, cryptosporidium_bin <dbl>, …
hist(abcd_data$lazd90)